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Patient-Reported Scores Valid, Reliable for Assessing HRQoL in AD


April 15, 2021

According to study findings published online in the Journal of the American Academy of Dermatology, Patient-Reported Outcomes Measurement Information System Global Health (PGH) scores had sufficient validity and reliability to assess health-related quality of life in atopic dermatitis (AD).  

“PGH was validated to assess health-related quality of life in several diseases. Little is known about its measurement properties in adult [AD],” study researchers wrote.  

Based on this, they sought to examine the measurement properties of these scores among adults with AD through a prospective dermatology practice-based study of 994 AD patients.  

Of the study participants, aged 18 to 97 years, the researchers found that PGH physical and mental health 4-item and abridged 2-item T scores, as well as mapped EuroQol-5D score had a strong to very strong correlation with each other. Further, “moderate to strong Spearman correlations with Patient-Oriented Scoring Atopic Dermatitis, Patient-Health Questionnaire–9, Patient-Reported Outcomes Measurement Information System sleep disturbance and related impairment, Eczema Area and Severity Index, objective Scoring Atopic Dermatitis; and weak to moderate correlations with Patient Oriented Eczema Measure, numeric rating scale worst itch and average itch, and Scoring Atopic Dermatitis.”  

Additional findings show that the Dermatology Life Quality Index (DLQI) “had stronger correlations with Patient Oriented Eczema Measure, Patient-Oriented Scoring Atopic Dermatitis, numeric rating scale worst itch and average itch, Eczema Area and Severity Index, and Scoring Atopic Dermatitis, but weaker correlations with Patient-Health Questionnaire–9 and Patient-Reported Outcomes Measurement Information System sleep disturbance and related impairment (convergent/divergent validity).”  

For self-reported global AD severity, the researchers found that PGH and DLQI had a similarly poor ability to differentiate between levels. Of important note, the researchers did not observe floor or ceiling effects, and there were no PGH or DLQI items that had differential items functioning by demographic.  

Finally, fair to good responsiveness was reported for PGH and DLQI scores. These scores also showed similarly good test-retest reliability.  

“PGH scores had sufficient validity and reliability to assess health-related quality of life in [AD],” the study authors concluded.  

Julie Gould

Reference:

Schwartzman G, Lei D, Yousaf M, et al. Validity and reliability of Patient-Reported Outcomes Measurement Information System Global Health scale in adults with atopic dermatitis [published online ahead of print, 2021 Jan 20]. J Am Acad Dermatol. 2021;S0190-9622(21)00180-8. doi:10.1016/j.jaad.2021.01.033

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